Table 3.
Subgroup analysis for OS.
| Subgroup | No. of studies | HR(95%CI) | P | Heterogeneity I2(%) | Ph |
|---|---|---|---|---|---|
| Population | |||||
| China | 3 | 2.38[1.17- 4.84] | 0.017 | 80.4 | 0.006 |
| Japan | 5 | 2.00[1.54-2.61] | <0.0001 | 15.6 | 0.315 |
| Sample size | |||||
| >140 | 4 | 1.67[1.37- 2.03] | <0.0001 | 0 | 0.558 |
| ≤140 | 4 | 3.23[2.07- 5.06] | <0.0001 | 27.3 | 0.248 |
| Study quality | |||||
| High | 3 | 4.08[2.55- 6.51] | <0.0001 | 0 | 0.587 |
| Low | 5 | 1.70[1.40- 2.05] | <0.0001 | 0 | 0.662 |
| Treatment method | |||||
| Surgical | 7 | 2.18[1.59- 2.98] | <0.0001 | 60.1 | 0.020 |
| Palliative care | 1 | 2.02[1.08- 3.80] | 0.028 | – | – |
| Cut-off | |||||
| 2 | 4 | 2.11[1.37- 3.26] | 0.001 | 48.1 | 0.123 |
| 3 | 3 | 2.43[1.24- 4.77] | 0.010 | 77.0 | 0.013 |
| 4 | 1 | 1.91[1.31- 2.76] | 0.001 | – | – |
| Tumor type | |||||
| Mixed | 2 | 1.65[1.29-2.10] | <0.0001 | 4.3 | 0.307 |
| CCA | 5 | 2.38[1.57-3.61] | <0.0001 | 57.6 | 0.051 |
| AVC | 1 | 3.98[1.49-10.64] | 0.006 | – | – |