TABLE 4.

Key Points of C. difficile Infection in Children

Key Points
• Clostridioides difficile infection (CDI) is an important cause of antibiotic-associated diarrhea and healthcare-associated infection in children.
• A multistep approach is currently recommended for diagnosis
• Newer treatment options for CDI in children include oral vancomycin and fidaxomicin
• Recurrence of CDI is common and presents a therapeutic challenge; fecal microbiome transplantation, an exploratory therapy to restore distorted microbial communities, is becoming more commonly used in children
• More child focused investigation is warranted to improve the burden of CDI in children