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. 2023 Aug 31;80(9):274. doi: 10.1007/s00018-023-04919-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Developmental EDC-induced reprogramming of rat MMSCs genes. a Five animals from each of the EDC diethylstilbestrol and VEH groups were pooled and subjected to MMSC isolation using a FACS strategy. Pie chart showing the percentage of genes that exhibited changes in RNA expression between EDC-MMSCs and VEH-MMSCs as measured by RNA-seq; the cutoff value is twofold with an FDR < 0.05. b List of the top 20 up-DEGs in EDC- vs. VEH-MMSCs. c List of the top 20 down-DEGs in EDC- vs. VEH-MMSCs. d Over-representation analysis showed that multiple UF-related pathways, including the estrogen response pathways (red color) were affected by early-life EDC exposure. e Relevant diseases affected by developmental EDC diethylstilbestrol exposure were analyzed by Ingenuity Pathway Analysis (IPA) and highlighted in red color