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. 2023 Aug 31;80(9):274. doi: 10.1007/s00018-023-04919-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Transcriptional profiling reveals reprogramming of estrogen-responsive gene. a Pie chart showing the percentage of ERGs that exhibited changes in RNA expression in EDC-MMSCs compared to VEH-MMSCs, as measured by RNA-seq. b List of the top 20 up-ERGs, that showed differential expression as measured by RNA-seq in EDC- vs. VEH-MMSCs. c List of the top 20 down-ERGs, that showed differential expression as measured by RNA-seq in EDC- vs. VEH-MMSCs. d ER-a is upregulated in EDC-MMSCs compared to VEH-MMSCs. Lysates were prepared from EDC-MMSCs and VEH-MMSCs and subjected to Western blot analysis using antibody against ER-a. e Luciferase activities in the presence or absence of estrogen (10 nM) were compared between EDC-MMSCs and VEH-MMSCs. f Alteration of ERG expression in the presence or absence of estrogen in DES-MMSCs and VEH-MMSCs. Student’s t-test, *p < 0.05; **p < 0.01; ***p < 0.001