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. 2023 Aug 31;80(9):274. doi: 10.1007/s00018-023-04919-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Developmental EDC exposure alters the methylome and reprograms ERGs via DNA promoter methylation. a Western blot analysis was performed to measure the protein levels of DNMT3A in VEH-MMSCs and EDC-MMSCs. b Heatmap of genes with DNA methylation in VEH- and EDC-MMSCs. c The methylation tracks of Esr1 determined by targeted bisulfite NGS, which covered 14 CpG sites located in its CpG island. d Percentage of EDC-regulated genes with status of H3K4me3 and DNA methylation. e Number of genes with status of H3K4me3 and DNA methylation. f Integrated genome viewer (IGV) plots and integration of multi-omic analysis. Peaks with H3K4me3 enrichment, DNA methylation, and RNA expression in EDC-MMSCs are indicated in red, while peaks with H3K4me3 enrichment, DNA methylation, and RNA expression in VEH-MMSCs are indicated in blue. Student’s t-test, ***p < 0.001