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. 2023 Aug 31;80(9):274. doi: 10.1007/s00018-023-04919-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Model for developmental reprogramming of the epigenome in MMSCs. Environmental risk factors, including EDC exposure, disrupt the epigenome via histone modification and DNA methylation, thereby leading to the conversion of MMSCs into UF-initiating cells, and eventually giving rise to the formation of UFs