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. 2023 Jul 2;48(10):3177–3189. doi: 10.1007/s11064-023-03964-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Comparison of the concentration-dependent effects of G6PDi-1 on the investigated parameters of cultured astrocytes. The specific values of cellular parameters that were found to be strongly affected in a concentration-dependent manner by the presence of G6PDi-1 (Table 4) were used to calculate the percental effect concentrations. For the calculations of the concentration-dependent effects of the parameters investigated, the values determined for the incubation with 100 µM G6PDi-1 were set as 100% and the values for the respective controls (absence of G6PDi-1) as 0%. From the curves obtained, the EC50 value were calculated and are given in Table 4. The colours of the symbols are indicating the investigated metabolic parameter (for more details see Table 4). The red dashed line is showing the 50% effects