Table 4.

Half-maximal effects of G6PDi-1 on astrocytic metabolic processes that involve G6PDH-dependent NADPH regeneration

	Original data	Incubation time	EC50
Test for	Figures	(min)	(µM)
WST1 reduction	3b	60	6.3 ± 2.2
Cellular loss of GSx	4a	120	4.2 ± 0.8
Extracellular GSx accumulation	4c	120	4.7 ± 2.0
Cellular GSSG accumulation	4b	10	3.2 ± 1.1
Extracellular GSSG accumulation	4d	120	4.4 ± 1.7

The concentrations of G6PDi-1 that inhibit half of the metabolic parameters investigated were calculated from the sigmoidal curves shown in Fig. 5