Table 2.

Related applications of CEMIP as a therapeutic target.

Transfer method	The molecules contained	Therapeutic target	Mechanism	Reference
NA	Anti-CEMIP monoclonal antibodies	The joints of mice with OA	Antibody neutralizes CEMIP	(13)
NA	PTX	Colon cancer cells	Stabilizing microtubules inhibited the promigratory effect of CEMIP	(10)
Core–shell drug depot	PTX and CEMIP-specific shRNA	MDA-MB-231	Tumor-specific penetration, targeted drugs release	(42)
Thermosensitive PLGA-PEG-PLGA polymer	Dox and CEMIP-specific shRNA	Mouse breast carcinoma 4 T1 cells	Tumor-specific penetration, targeted and quantitative drug release	(43)

NA, not applicable.