Table 3.

(A) Sample size for the overall population (alpha=0.05). (B) Sample size for high-risk group (alpha=0.05). (C) Sample size by region (alpha=0.025)

Baseline risk	Risk reduction	Evaluable sample size per arm
		Power=0.80	Power=0.85	Power=0.90
(A)
3%	20%	11 455	13 103	15 334
3%	25%	7133	8159	9548
3%	30%	4815	5508	6446
8%	20%	4096	4686	5483
8%	25%	2554	2921	3419
8%	30%	1727	1975	2311
14%	20%	2204	2521	2950
14%	25%	1377	1575	1842
14%	30%	932	1066	1247
(B)
6%	20%	5568	6369	7453
6%	25%	3470	3969	4644
6%	30%	2344	2681	3138
(C)
8%	20%	4961	5607	6477
8%	25%	3093	3496	4038
8%	30%	2091	2363	2729
14%	20%	2669	3017	3485
14%	25%	1677	1884	2176
14%	30%	1129	1276	1474