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. 2023 Aug 31;6(11):e202302271. doi: 10.26508/lsa.202302271

Figure 1. Investigated blood cell types.

Figure 1.

Haematopoietic differentiation: blood cells are derived from haematopoietic stem cells in the bone marrow; these give rise to highly proliferative CD34+ progenitors (red) which occur infrequently in peripheral blood. Monocyte (blue), granulocytes (grey), dendritic (orange), and natural killer (NK; light purple) cells are involved in the innate immune response. B (dark purple) and T (green) lymphocytes communicate with these cells to generate the highly specific adaptive immune response; B and T memory cells remain after clearance of a pathogen to defend against reinfection. Dashed line represents differentiation yet to be validated. HSC, haematopoietic stem cell; MPP, multipotent progenitors; LMPP, lymphoid-primed multipotent progenitors; MLP, multilymphoid progenitors; ETP, early T cell precursor; B/NK, B and NK cell progenitor GMP, granulocyte–macrophage progenitors; MEP, megakaryocyte–erythroid progenitor; Eo/Baso, eosinophil/basophil; CM, central memory T cell; EM, effector memory T cell; TEMRA, terminal effector cell (CD45RA+ effector memory T cell); NK, natural killer cell; pDC, plasmacytoid dendritic cell; mDC, myeloid dendritic cell.