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GII.17-cluster IIIb blocking serum and mAbs exhibit neutralization activity in human intestinal enteroid cultures. Single-dose neutralization of GII.17 cluster IIIb in HIE. Each sample was tested at a single concentration (serum diluted 1:100 and mAb at ~1 µg/mL) against a fixed virus concentration (100 TCID50). Virus control (no antibody) was included. Norovirus replication was assessed by RT-qPCR at 3 days post-infection (dpi). Results are expressed as genomic copies per well.
