Table 2. Change in fasting plasma lipids.

	Baseline	8 weeks	16 weeks	24 weeks	52 weeks	Controls
Total triglyceride (mmol/l)	1.4 (1.1–1.7)	1.2  (0.9–1.5) P=0.0110	0.9  (0.8–1.2) P < 0.0001	0.9  (0.6–1.1) P<0.0001	0.9  (0.7–1.1) P=0.0042	0.8  (0.6–1.1) P=0.520
VLDL triglyceride (mmol/l)	0.35  (0.30–0.61)	0.30  (0.19–0.50) P=0.186	0.22  (0.15–0.29) P=0.001	0.22  (0.16–0.24) P=0.002	0.24  (0.17–0.32) P=0.021	0.21  (0.15–0.29) P=0.676
Chylomicron triglyceride (mmol/l)	0.33 ± 0.4	0.28 ± 0.05 P=0.012	0.20 ± 0.03 P=0.0001	0.16 ± 0.04 P=0.002	0.27 ± 0.08 P=0.128	0.23 ± 0.03 P=0.597
Total cholesterol (mmol/l)	4.7 ± 0.2	4.4 ± 0.2 P=0.042	4.1 ± 0.2 P=0.003	4.3 ± 0.3 P=0.073	4.4 ± 0.2 P=0.103	4.9 ± 0.3 P=0.115
HDL cholesterol (mmol/l)	1.4 ± 0.1	1.4 ± 0.1 P=1.000	1.4 ± 0.1 P=0.163	1.7 ± 0.1 P=0.004	1.6 ± 0.1 P=0.001	1.7 ± 0.1 P=0.255
LDL cholesterol (mmol/l)	2.9 ± 0.2	2.5 ± 0.2 P=0.081	2.2 ± 0.2 P=0.007	2.3 ± 0.2 P=0.280	2.4 ± 0.2 P=0.207	2.8 ± 0.3 P=0.244
Cholesterol/HDL ratio	3.4 ± 0.2	3.3 ± 0.1 P=0.185	2.9 ± 0.1 P=0.001	2.6 ± 0.2 P=0.024	2.8 ± 0.2 P=0.001	2.9 ± 0.2 P=0.595
Non-esterified fatty acids (mmol/l)	0.72 ± 0.04	0.60 ± 0.05 P=0.077	0.61 ± 0.04 P=0.185	0.82 ± 0.13 P=0.732	0.57 ± 0.04 P=0.155	0.6 ± 0.1 P=0.463
Ketones (mmol/l)	0.19 ± 0.02	0.24 ± 0.02 P=0.049	0.38 ± 0.11 P=0.087	0.40 ± 0.07 P=0.021	0.30 ± 0.07 P=0.150	0.23 ± 0.02 P=0.361

Mean ± SEM or median (IQR). Significance stated as paired analysis from baseline for each time point (all confirmed by Benjamini–Hochberg correction). The P-values for each time point versus baseline are shown. Significance of difference shown in control column is in comparison with the 52-week T2D time point.