Table 3. Adipokines at baseline and after each weight loss period.
| Baseline | 8 weeks | 16 weeks | 24 weeks | 52 weeks | Controls | |
|---|---|---|---|---|---|---|
| n=20 | n=20 | n=19 | n=8 | n=15 | n=20 | |
| PAI-1 (ng/ml) | 8.64 (6.41–11.22) | 5.99* (3.67–7.84) P=0.006 |
5.44 (3.65–8.69)* P<0.001 |
4.94 (4.23–8.52)* P=0.008 |
6.31 (4.63–9.36)* P=0.007 |
4.87 (3.49–8.47) P=0.250 |
| hsCRP (ng/ml) | 815 (556–1951) | 854 (475–1302) P=0.048 |
848 (406–2595) P=0.829 |
654 (246–765) P=0.195 |
386 (281–751) P=0.035 |
563 (225–1247) P=0.677 |
| IL6 (pg/ml) | 1.16 (0.88–1.72) | 1.44 (0.97–1.60) P=0.956 |
1.25 (0.88–1.81) P=0.196 |
0.79 (0.66–1.94) P=0.039 |
1.06 (0.67–1.37) P=0.041 |
0.88 (0.72–1.74) P=0.641 |
| Leptin (ng/ml) | 442 (266–744) | 312 (112–499)* P<0.001 |
224 (133–343)* P<0.001 |
208 (67–338)* P=0.008 |
299 (123–513)* P<0.001 |
227 (162–290) P=0.474 |
| Adiponectin (ng/ml) | 1364 (1106–2396) | 1875 (1261–2587) P=0.202 |
1842 (1345–3090) P=0.049 |
2881 (1378–4518)* P=0.008 |
1854 (1596–4512)* P=0.005 |
2287 (1630–2727) P=0.934 |
| FGF-21 (pg/ml) | 425 (258–666) | 308 (197–814) P=0.546 |
298 (160–619)* P=0.003 |
248 (130–547)* P=0.008 |
330 (114–1192) P=0.252 |
362 (249–2842) P=0.264 |
| GDF-15 (pg/ml) | 591 (411–879) | 444 (347–555) P=0.105 |
457 (356–627) P=0.080 |
355 (341–610) P=0.039† |
502 (381–736) P=0.978 |
446 (372–620) P=0.7260 |
Median (IQ range). Benjamini–Hochberg correction confirmed the significance of difference from baseline with one exception.† The P-values for each time point versus baseline are shown. The P-values for difference between Controls and the 12-month (P4) data for the type 2 diabetes participants are shown in the Controls column.