Table 5.

Excretion and toxicity profile of native ligand and natural polymers.

Code	Excretion		Toxicity
	CL	T1/2	H-HT	DILI	AMES toxicity	Rat oral acute toxicity	FDAMDD	Skin sensitization	Carcinogenicity	Eye corrosion	Eye irritation	Respiratory toxicity
NL	6.982	0.078	0.546	0.988	0.209	0.755	0.902	0.042	0.24	0.003	0.007	0.903
Agarose	0.622	0.872	0.065	0.077	0.086	0.137	0.0	0.461	0.041	0.003	0.028	0.028
Alginate	1.579	0.752	0.127	0.892	0.03	0.401	0.001	0.019	0.01	0.003	0.006	0.024
Carrageenan	6.66	0.277	0.37	0.954	0.438	0.907	0.933	0.089	0.078	0.003	0.009	0.402
Chitosan	−2.095	0.982	0.122	0.044	0.027	0	0	0.04	0	0.004	0.004	0.007
Cyclodextrin	−0.191	0.905	0.124	0.765	0.038	0.015	0.0	0.009	0.001	0.003	0.004	0.002
Dextran	0.607	0.746	0.116	0.863	0.084	0.039	0.0	0.007	0.002	0.003	0.007	0.004
Hyaluronic acid	0.671	0.897	0.252	0.935	0.056	0.0	0.0	0.016	0.001	0.003	0.01	0.0
Polysialic acid	1.461	0.724	0.142	0.183	0.018	0.0	0.003	0.054	0.002	0.003	0.039	0.009