Figure 1.

Considerations in the management and treatment of CNS metastases in NSCLC in an Australian setting. ^∗Patients with poor performance status who are unfit for anticancer therapy may be considered for best supportive care. Earlier initiation of CNS active systemic therapies may be considered for eligible patients with high extracranial disease burden and mildly symptomatic brain lesions. ⁺Small tumors <30 mm are treated with SRS, large tumors ≥30 mm are treated with surgery.⁶ CNS, central nervous system; MDT, multidisciplinary team; PBS, pharmaceutical benefits scheme; SRS, stereotactic radiosurgery; WBRT, whole-brain radiotherapy.