FIGURE 3.

Hydrogen sulphide (H₂S) synthase has different functions in colorectal cancer, which may be due to the crosstalk between different molecules and the high concentration of H₂S in the intestinal environment. However, in general, inhibition of endogenous H₂S can inhibit tumour growth. 3‐MST, 3‐mercaptopyruvate sulfurtransferase; ACLY, ATP citrate lyase; AP1, activating protein 1; ATP, adenosine triphosphate; CBS, cystathionine β‐synthase; CD44, a transmembrane glycoprotein and an important biomarker of cancer stem cells; CSE, cystathionine γ‐lyase; EREG, epiregulin; GAPDH, glyceraldehyde‐3‐phosphate dehydrogenase; GSH, glutathione; OTUB1, OTU domain‐containing ubiquitin aldehyde‐binding protein 1; PCNA, proliferating cell nuclear antigen; PTGS, prostaglandin‐endoperoxide synthase; ROS, reactive oxygen species; Sp1, specificity protein 1; Sp3, transcription factor Sp3; ‐SSH, S‐sulfhydration; TYMS, thymidylate synthetase; VEGF, vascular endothelial growth factor; xCT, SLC7A11.