Table 1.
Variants associated with ALT elevation case-control analysis (p-value < 1 × 10− 5)
| SNP | CHR | BP | A1 | A2 | F_A | F_U | OR | SE | L95 | U95 | P | Gene | annot | dist |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs818165 | 2 | 10,613,284 | A | G | 0.1905 | 0.4574 | 0.2791 | 0.3025 | 0.1543 | 0.5049 | 7.30 × 10− 6 | AC007249.3 | intergenic | 17,606 |
| NOL10 | intergenic | 97,608 | ||||||||||||
| rs12188529 | 5 | 16,529,754 | A | G | 0.2143 | 0.4929 | 0.2806 | 0.2914 | 0.1585 | 0.4967 | 4.82 × 10− 6 | FAM134B | intronic | 0 |
| rs3865350 | 17 | 5,381,867 | C | T | 0.7143 | 0.4007 | 3.739 | 0.2704 | 2.201 | 6.352 | 4.63 × 10− 7 | DERL2 | intronic | 0 |
| rs2309399 | 17 | 5,391,690 | G | A | 0.7143 | 0.4043 | 3.684 | 0.2703 | 2.169 | 6.258 | 8.40 × 10− 7 | MIS12 | UTR5 | 0 |
| kgp8586964 | 17 | 5,409,097 | G | T | 0.7024 | 0.4071 | 3.436 | 0.2679 | 2.033 | 5.809 | 3.02 × 10− 6 | NLRP1 | intronic | 0 |
CHR: Chromosome; SNP: SNP ID; BP: Physical position (base-pair)in reference to genome build 37; A1: Minor allele name (based on whole sample); F_A: Frequency of A1 allele in cases; F_U: Frequency of A1 allele in controls; A2: Major allele name; P: Exact p-value; OR: Estimated odds ratio (for A1); L95: Lower bound of 95% confidence interval for odds ratio; U95: Upper bound of 95% confidence interval for odds ratio