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. 2023 Aug 31;24:199. doi: 10.1186/s13059-023-03031-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Single-cell transcriptome landscape of human normal hematopoiesis. a UMAP visualization of healthy human hematopoietic cells (n = 155,574 cells), with each dot representing a cell and colors indicating distinct cell types. The inset plot provides an enlarged view of the six HSPC clusters, including HSC (hematopoietic stem cell), LMPP (lymphoid-primed multi-potential progenitor), GMP (granulocyte–macrophage progenitor), CLP (common lymphoid progenitor), MEP (megakaryocyte (MK) and erythroid progenitor), and E/B/M (eosinophil/basophil/mast cell progenitor) that express three lineages-specific canonical markers and MEP commitment-essential transcription factors, consistent with previous reports [14–17]. b Heatmap illustrating cell type-specific gene expression (rows) across various HSPC populations (columns). c GSEA plots showing the representative gene signatures enriched in HSC, LMPP, and GMP populations with accompanying normalized enrichment score (NES), p value, and false discovery rate (FDR) value. d Dot plot representing the expression of representative genes involved in indicated biological processes in HSC, LMPP, and GMP populations. Dot size signifies the proportion of cells expressing a gene in a cell population, while shading represents the relative expression level