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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: ACS Nano. 2022 Mar 28;16(4):6349–6358. doi: 10.1021/acsnano.2c00423

Fig. 6. Extravasation does not involve extracellular vesicle transport:

Fig. 6.

A) Possible nanomedicine extravasation pathways include active transport/transcytosis, passive diffusion via gaps, incorporation of liposomes in extracellular vesicle biogenesis, and leukocyte hitchhiking; B) Representative images of foot skin sections stained for EV marker CD81 1h post-injection of DiI labeled EPC/DSPE-PEG2000 liposomes; C) line profile drawn across multiple extravasated DiI+ liposomes shows almost no colocalization with CD81. Experiment repeated twice.