Table 3.

Hazard ratios of the four principal components for all-cause mortality

Component	Main model (N = 84,877) HR (95% CI)	Sensitivity model (N = 62,771) HR (95% CI)
fPC1
-2:0	1.69 (1.57–1.81)	1.77 (1.63–1.93)
-1:0	1.20 (1.14–1.27)	1.22 (1.14–1.30)
1:0	0.94 (0.88–0.99)	0.94 (0.87–1.00)
2:0	0.91 (0.84–0.99)	0.92 (0.84–1.02)
Overall p-value	6.25 × 10–56	3.43 × 10–50
fPC2	0.98 (0.94–1.03)	0.98 (0.93–1.04)
Overall p-value	0.395	0.554
fPC3	0.88 (0.83–0.93)	0.89 (0.83–0.95)
Overall p-value	2.02 × 10–6	3.43 × 10–7
fPC4	1.16 (1.08–1.25)	1.15 (1.05–1.26)
Overall p-value	1.08 × 10–5	0.003

HRs are reported for a one score increase except for fPC1, where HRs for a score of -2, -1, + 1, and + 2 compared to 0 are reported. The main model was stratified by sex and study center and was further adjusted for prevalent CVD and diabetes, smoking status, alcohol consumption status, socio-economic status, education level, sedentary behavior, and diet. The sensitivity model was adjusted for pack years of smoking and alcohol grams per day instead of smoking status and alcohol consumption status