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. 2023 Sep 1;24:512. doi: 10.1186/s12864-023-09576-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Motifs and transcription factor binding sites with significant enrichment within more accessible regions upon RPOA-2 and GRWD-1 depletion. A Left: Comparative motif analyses (STREME) of differentially accessible regions reveal similar motifs that are significantly enriched among regions that become more accessible following RPOA-2 and GRWD-1 depletion. Middle: The numbers of regions becoming significantly more accessible upon RPOA-2 and GRWD-1 depletion, which also show enrichment for the corresponding motif, are shown along with their respective percentages. Right: Close examination of the significant motifs revealed similarities to the EOR-1 binding site, which was downloaded from the JASPAR database [28], with colors adjusted accordingly. B We assessed significant enrichment across transcription factor binding sites or histone modification sites using data from ChipAtlas [29, 30]. This data was filtered based on significance (Q value < -2), specificity to the L1 stage, and inclusion in at least four different experiments. The y-axis displays relative enrichment, the x-axis shows different transcription factors and histone modifications, and each point represents a single experiment