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Expression and modification of GPX4. (A) Multiple transcription factors are required for GPX4 expression. As a selenoprotein, Sec-tRNA[Ser]Sec requires a Sec insertion sequence element in Gpx4 mRNA. (B) GPX4 can undergo ubiquitination (Ub), phosphorylation (P), sumoylation (Su) and alkylation (Alk) at specific sites. (C) Both the UPS and autophagy are involved in GPX4 protein degradation.
