Table 3.

Binding energy results in kcal/mol for the tested hybrids versus the co-crystallised ligands.

Compound	DprE1 (pdb: 4KW5) Energy score (kcal/mol)	TMPKmt (pdb: 1W2H) Energy score (kcal/mol)
5c	−21.5	−19.7
15	−19.8	−18.4
The co-crystallised ligand	−20.3	−17.9