Table 2.
Outcomes of ultra-long, long, antagonist, and short protocols in fresh ET cycles.
| Ultra-long protocol | Long protocol | Antagonist protocol | Short protocol | Padjust | |
|---|---|---|---|---|---|
| No. of cycles | 108 | 56 | 34 | 59 | |
| Total dosage of Gn, IU | 2775.00 (2250.00,3993.75)acf | 1800.00 (1500.00,2325.00)c | 2175.00 (1656.25,2728.12)f | 1975.00 (1425.00,2700.00)a | <0.001 |
| Duration of Gn stimulation, days | 11.00 (10.00,12.25)acf | 9.00 (9.00,11.00)c | 9.00 (8.00,10.00)f | 9.00 (7.50,10.00)a | <0.001 |
| LH on HCG trigger day, IU/L | 1.04 (0.56,1.59)acf | 2.30 (1.43,3.05)bc | 2.51 (1.80,5.54)df | 5.24 (3.80,7.04)abd | <0.001 |
| E2 on HCG trigger day, pg/ml | 2061.50 (1407.75,2884.25) | 2650.50 (1708.00,3468.25)be | 1653.50 (1081.00,2172.25)e | 1619.00 (1294.50,2575.50)b | <0.001 |
| P on HCG trigger day, ng/ml | 0.66 (0.46,0.84) | 0.58 (0.44,0.94) | 0.46 (0.35,0.80) | 0.65 (0.39,0.81) | 0.549 |
| Endometrial thickness on HCG trigger day, cm | 1.10 (0.90,1.20)a | 1.10 (0.90,1.25)b | 1.00 (0.80,1.10) | 0.90 (0.80,1.10)ab | 0.002 |
| No. of oocytes retrieved | 7.00 (4.75,12.00)a | 10.00 (6.00,12.00)b | 6.00 (3.00,9.75) | 4.00 (3.00,8.00)ab | <0.001 |
| No. of 2PN zygotes retrieved | 5.00 (3.00,7.25)a | 6.00 (4.00,9.00)b | 4.00 (2.25,6.50) | 3.00 (2.00,5.00)ab | <0.001 |
| No. of high-quality embryos retrieved on Day 3 | 2.00 (1.00,4.00)c | 4.00 (2.00,6.00)bc | 2.00 (2.00,4.00) | 2.00 (1.00,3.00)b | <0.001 |
| Pregnancy outcomes, %(n/N) | |||||
| IR | 49.7 (85/171)a | 52.1 (49/94)b | 33.3 (18/54) | 28.2 (24/85)ab | 0.001 |
| BPR | 10.2 (11/108) | 10.7 (6/56) | 11.8 (4/34) | 8.5 (5/59) | 0.960 |
| EPR | 0.01 (1/108) | – | – | – | – |
| CPR | 57.4 (62/108)a | 64.3 (36/56)b | 38.2 (13/34) | 35.6 (21/59)ab | 0.004 |
| MR | 30.6 (19/62) | 25.0 (9/36) | 30.8 (4/13) | 42.9 (9/21) | 0.575 |
| Early MR | 16.1 (10/62) | 22.2 (8/36) | 23.1 (3/13) | 38.1 (8/21) | 0.230g |
| Late MR | 14.5 (9/62) | 2.8 (1/36) | 7.7 (1/13) | 4.8 (1/21) | 0.241g |
| LBR | 39.8 (43/108) | 48.2 (27/56)b | 26.5 (9/34) | 20.3 (12/59)b | 0.007 |
Data were presented as median (25th-75th percentile) for non-normality distribution variables. Gn, gonadotropin; LH, luteinizing hormone; E2, estradiol; P, progesterone; HCG, human
chorionic gonadotropin IR, implantation rate; BPR, biochemical pregnancy rate; EPR, ectopic pregnancy rate; CPR, clinical pregnancy rate; MR: miscarriage rate; LBR, live birth rate.
aultra-long vs short; blong vs short; cultra-long vs long; dantagonist vs short; elong vs antagonist; fultra-long vs antagonist; gFisher’s exact test.