Table 4.
Outcomes of FET and characteristics of frozen embryo originating COS cycles.
| Ultra-long protocol | Long protocol | Antagonist protocol | Short protocol | Padjust | |
|---|---|---|---|---|---|
| No. of cycles | 98 | 101 | 54 | 52 | |
| Total dosage of Gn, IU | 2512.50 (2025.00,3862.50)acf | 2025.00 (1500.00,2775.00)c | 1875.00 (1418.75,2531.25)f | 2025.00 (1556.25,2625.00)a | <0.001 |
| Duration of Gn stimulation, days | 11.00 (10.00,12.75)acf | 10.00 (9.00,12.00)c | 9.00 (9.00,11.00)f | 9.00 (8.00,10.25)a | <0.001 |
| LH on HCG trigger day, IU/L | 1.00 (0.57,1.40)acf | 1.74 (1.15,2.61)bce | 3.28 (1.98,4.92)ef | 4.79 (3.40,6.50)ab | <0.001 |
| E2 on HCG trigger day, pg/ml | 3117.00 (2445.00,4806.75)a | 3000.00 (2373.00,4300.00)b | 2158.00 (1741.00,4566.25) | 2131.50 (1597.75,3408.25)ab | <0.001 |
| P on HCG trigger day, ng/ml | 0.75 (0.53,0.99) | 0.74 (0.50,1.08) | 0.83 (0.43,1.18) | 0.71 (0.43,0.91) | 0.542 |
| Endometrial thickness on HCG trigger day, cm | 0.90 (0.80,1.00) | 0.90 (0.80,1.00) | 0.90 (0.80,1.00) | 0.88 (0.80,1.00) | 0.676 |
| No. of oocytes retrieved | 12.00 (9.00,17.75)a | 12.00 (10.00,16.00)b | 11.00 (5.25,15.00)d | 6.50 (4.00,8.25)abd | <0.001 |
| No. of 2PN zygotes retrieved | 7.00 (5.00,12.00)a | 8.00 (6.00,10.00)b | 6.50 (4.00,10.00)d | 4.00 (3.00,6.00)abd | <0.001 |
| No. of high-quality embryos retrieved on Day 3 | 4.00 (2.00,6.00) | 5.00 (3.00,8.00)b | 3.00 (1.25,6.00) | 3.00 (2.00,4.00)b | <0.001 |
| Pregnancy outcomes, %(n/N) | |||||
| IR | 45.5 (45/99) | 47.2 (51/108) | 41.8 (23/55) | 50.0 (26/52) | 0.851 |
| BPR | 56.1(55/98) | 56.4 (57/101) | 46.3 (25/54) | 63.5 (33/52) | 0.313 |
| EPR | – | – | – | 0.02 (1/52) | – |
| CPR | 43.9 (43/98) | 49.5 (50/101) | 40.7 (22/54) | 50.0 (26/52) | 0.658 |
| MR | 41.9 (18/43) | 32.0 (16/50) | 45.5 (10/22) | 38.5 (10/26) | 0.791 |
| Early MR | 27.9 (12/43) | 32.0 (16/50) | 36.4 (8/22) | 30.8 (8/26) | 0.917 |
| Late MR | 14.0 (6/43) | – | 9.1 (2/22) | 7.7 (2/26) | 0.120g |
| LBR | 25.5 (25/98) | 33.7 (34/101) | 22.2 (12/54) | 30.8 (16/52) | 0.403 |
| CLBR | 46.2(67/145)c | 68.2(60/88)bce | 36.2(21/58)e | 35.9(21/58)b | <0.001 |
| CLBRhypo | 59.8(116/194)c | 76.5(91/119)bce | 50.7(38/75)e | 49(48/98)b | <0.001 |
Data were presented as median (25th-75th percentile) for non-normality distribution variables. Gn, gonadotropin; LH, luteinizing hormone; E2, estradiol; P, progesterone; HCG, human
chorionic gonadotropin IR, implantation rate; BPR, biochemical pregnancy rate; EPR, ectopic pregnancy rate; CPR, clinical pregnancy rate; MR, miscarriage rate; LBR, live birth rate;
CLBR, cumulative live birth rate, was calculated based on current finished embryo transfer cycles. CLBRhypo was calculated by hypothesizing that all surplus embryos were transferred and
live birth was achieved. aultra-long vs short; blong vs short; cultra-long vs long; dantagonist vs short; elong vs antagonist; fultra-long vs antagonist; gFisher’s exact test.