Table 3.

Fixed effects of the linear mixed regression model for the association between determinants and door-in-door out time (min).

Door-in-door-out time, min	Univariable regression coefficient (95% CI)	Multivariable regression coefficient (95% CI)
Age
Per 10 years	3.9 (0.01 to 7.9)	5.6 (2.1 to 9.1)
Sex
Male	Reference	–
Female	3.3 (−7.5 to 14.1)	–
Pre-stroke mRS
mRS 0–2	Reference	–
mRS 3–5	3.3 (−10.9 to 17.6)	–
Hypertension at PSC
No	Reference	–
Yes	4.8 (−11.1 to 20.7)	–
Time of presentation
During office hours	Reference	–
Outside office hours	2.5 (−8.4 to 13.3)	–
Type of onset
Witnessed	Reference	Reference
Last known well	13.2 (2.5 to 23.8)	1.1 (−10.9 to 13.2)
Onset-to-door time
Within 6 h	Reference	Reference
Outside 6 h	21.5 (9.6 to 33.4)	19.8 (4.9 to 34.6)
Administration of IVT
No	Reference	Reference
Yes	−16.0 (−26.4 to −5.6)	−7.7 (−18.6 to 3.2)
Acquisition of CTP
No	Reference	–
Yes	5.2 (−7.8 to 18.2)	–
NIHSS at intervention centre
Per point	−0.8 (−1.5 to −0.02)	−0.4 (−1.2 to 0.4)
Occlusion side
Left	Reference	Reference
Right	10.8 (0.1 to 21.4)	11.9 (2.5 to 21.3)
Occlusion segment
ICA-T/M1	Reference	Reference
M2	15.0 (4.4 to 25.6)	14.9 (4.1 to 25.6)
Location of initial patient workup
CT-room	Reference	–
ED-room	2.1 (−10.5 to 14.7)	–
Location of CT-room
Emergency department	Reference	–
Elsewhere in hospital	−3.6 (−14.6 to 7.3)	–
Transfer notification order
Ambulance first	Reference	–
Intervention centre first	−1.6 (−12.5 to 9.3)	–
Stroke alarm notification
Emergency department	Reference	–
Neurologist	2.9 (−8.3 to 14.1)	–

CI: confidence interval; mRS: modified Rankin Scale; PSC: primary stroke centre; IVT: intravenous thrombolysis; CTP: computed tomography perfusion scan; NIHSS: National Institutes of Health Stroke Scale.

Data reported are coefficients with 95% confidence interval.