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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: eGastroenterology. 2023 Aug 18;1(1):e100013. doi: 10.1136/egastro-2023-100013

Figure 1.

Figure 1

Schematic representation of ethanol metabolism in the gastrointestinal tract. Ethanol is metabolised first in the stomach and absorbed principally in the proximal small gut by simple diffusion. The liver is the major organ involved in ethanol metabolism. Acetaldehyde and acetate can potentially accumulate in the intestine and promote/contribute to ABD pathogenesis. ABD, alcohol-associated bowel disease; ADH, alcohol dehydrogenase; ALDH, acetaldehyde dehydrogenase; CYP2E1, cytochrome P450-2E1.