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. 2023 Jul 25;94(Suppl 1):S319–S333. doi: 10.3233/JAD-221070

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© 2023 – The authors. Published by IOS Press

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1 — Structure of TREM2–DAP adaptor complex: The figure explains the composition of TREM2 in Plasma membrane and its complex formation with DAP 10 and 12 complex. TREM2, Triggering receptor expressed on myeloid cells 2; DAP 12 and 10, DNAX activation proteins 12 and 10; ITAM, Immunoreceptor tyrosine based activation motif; YINM, tyrosine-isoleucine-asparagine-methionine; SYK, Spleen tyrosine kinase; PI3K, Phosphatidyl inositol 3-kinase; sTREM2, Soluble TREM2; ADAM 10 and 17, α-secretase-disintegrin and metalloproteinase domain containing proteins 10 and 17.