Fig. 3.

A proposed mechanism for RSV against Aβ mediated impaired neurogenesis. The figure describes the possibilities of how Aβ induces aberrant Wnt activity resulting in apoptosis. 1) RSV treatment-mediated intracellular increase of SIRT1 activity may decrease the expression of Dkk1 protein levels thereby facilitating positive Wnt signaling. 2) Blocked on Wnt signaling at the extracellular level by Aβ can be surpassed by RSV-mediated SIRT1 enhancement at the level of activation of Dvl and disassociate the β-catenin destruction complex β-catenin phosphorylation, 3) Enhanced SIRT1 levels in vivo may directly deacetylate β-catenin thereby promoting its translocation into the nucleus independent of the ligand, 4) RSV mediated SIRT1 activity might deacetylate GSK3β by which it may prevent the destruction of β-catenin. Overall, the action of SIRT1 on these key events that promote Wnt signaling to a positive cell cycle might enhance the neurogenic process in AD-like conditions thereby facilitating neural regeneration.