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. 2023 Jul 20;85(9):4248–4255. doi: 10.1097/MS9.0000000000001074

Table 2.

Cox regression univariate and multivariate survival analysis.

Univariate analysis Multivariate analysis
Variable HR (95% CI) P HR (95% CI) P
IMW
 No 1 1
 Yes 0.47 (0.28–0.78) <0.01 0.43 (0.22–0.86) 0.02
Sex
 Male 1
 Female 1.09 (0.63–1.87) 0.54
ECOG
 0 1 1
 1 0.24 (0.12–0.49) <0.01 0.20 (0.77–0.54) <0.01
 2 0.72 (0.36–1.46) 0.37 0.53 (0.19–1.42) 0.21
 3 11.51 (3.94–33.57) <0.01 8.56 (2.26–32.48) <0.01
WHO histopathology
 Grade 1–2 1
 Grade 3 0.79 (0.43–1.43) 0.43
Clinical stage
 Stage 3 1 1
 Stage 4 1.76 (0.93–3.33) 0.07 1.59 (0.77–3.27) 0.21
Distant metastasis
 No 1 1
 Yes 1.5 (0.87–2.57) 0.56 1.92 (1.03–3.56) 0.04
Comorbidity
 No 1
 Yes 1.27 (0.74–2.18) 0.38
Treatment approach
 Palliative therapy 1 1
 Sequential CRT 0.31 (0.11–0.73) 0.04 0.24 (0.08–0.72) 0.01
 Concurrent CRT 0.17 (0.81–0.35) <0.01 0.27 (0.06–1.09) 0.07
 Chemotherapy only 2.66 (0.55–12.97) 0.22 7.32 (0.98–55.98) 0.06
 Radiotherapy only 0.09 (0.11–0.73) 0.02 0.42 (0.01–0.62) 0.02

CRT, chemoradiotherapy; ECOG, Eastern Cooperative Oncology Group; IMW, independent multidisciplinary work.