Table 3.
Factors Associated with 6-Month Functional Outcome After Aneurysmal Subarachnoid Hemorrhage
| Poor Prognosis | Good Prognosis | P value | |
|---|---|---|---|
| Demographic data | |||
| Gender (male/female) | 19/29 | 40/47 | 0.473 |
| Age (years) | 53.7±11.0 | 51.3±10.5 | 0.224 |
| Body mass index (kg/m2) | 23.1±2.4 | 23.8±2.6 | 0.146 |
| Adverse lifestyle habits | |||
| Cigarette smoking | 17 (35.4%) | 24 (27.6%) | 0.344 |
| Alcohol consumption | 16 (33.3%) | 21 (24.1%) | 0.252 |
| Chronic diseases | |||
| Hypertension | 11 (22.9%) | 14 (16.1%) | 0.328 |
| Diabetes mellitus | 6 (12.5%) | 8 (9.2%) | 0.547 |
| Dyslipidemia | 11 (22.9%) | 19 (21.8%) | 0.885 |
| Coronary heart disease | 2 (4.2%) | 5 (5.7%) | 0.692 |
| Medication history | |||
| Statin use | 6 (12.5%) | 14 (16.1%) | 0.574 |
| Anticoagulant use | 3 (6.3%) | 4 (4.6%) | 0.699 |
| Antiplatelet use | 5 (10.4%) | 8 (9.2%) | 0.818 |
| Antihypertensive use | 8 (16.7%) | 13 (14.9%) | 0.791 |
| Hypoglycemic or insulin use | 4 (8.3%) | 7 (8.1%) | 0.953 |
| Vital signs | |||
| Systolic arterial blood pressure (mmHg) | 130.3±21.9 | 131.5±21.1 | 0.754 |
| Diastolic arterial blood pressure (mmHg) | 81.8±12.7 | 82.0±13.6 | 0.935 |
| Mean arterial blood pressure (mmHg) | 106.0±16.6 | 106.7±16.2 | 0.812 |
| Severity scales | |||
| Hunt-Hess scores | 3 (3–4) | 2 (1–3) | <0.001 |
| Modified Fisher scores | 3 (3–3) | 2 (1–2.5) | <0.001 |
| Aneurysm-related parameters | |||
| Position (posterior/anterior circulation) | 13/35 | 18/69 | 0.398 |
| Shape (cystic/others) | 38/10 | 75/12 | 0.289 |
| Diameter (<10 mm/≥10 mm) | 25/23 | 49/38 | 0.636 |
| Treatments (clipping/endovascular) | 18/30 | 35/52 | 0.756 |
| External ventricular drain | 12 (25.0%) | 10 (11.5%) | 0.042 |
| Complications | |||
| Acute hydrocephalus | 13 (27.1%) | 11 (12.6%) | 0.036 |
| Intraventricular bleeding | 12 (25.0%) | 10 (11.5%) | 0.042 |
| Pneumonia | 12 (25.0%) | 14 (16.1%) | 0.209 |
| Seizure | 8 (16.7%) | 9 (10.3%) | 0.289 |
| Biochemical indices | |||
| Blood glucose levels (mmol/l) | 10.1 (7.3–16.5) | 8.7 (7.1–11.1) | 0.025 |
| Blood leukocyte count (×109/l) | 9.4 (6.8–11.5) | 7.1 (4.8–12.1) | 0.051 |
| Serum sestrin2 levels (ng/mL) | 10.0 (8.3–11.6) | 6.1 (1.3–9.1) | <0.001 |
| Others | |||
| Admission time (h) | 8.8 (4.6–13.5) | 8.5 (4.4–13.9) | 0.744 |
| Blood-collection time (h) | 9.5 (5.3–14.6) | 9.3 (5.1–14.6) | 0.749 |
Notes: Variables were shown as number (percentage), mean + standard deviation or median (percentiles 25th-75th) as appropriate and statistical methods included the student t-test, Mann–Whitney test, Fisher’s exact test and χ2 test.