Table 1. Study population.
| All | Pre-Xpert* | Xpert | ||||
|---|---|---|---|---|---|---|
| N = 749 | N = 247 | N = 502 | ||||
| Sex = Female (%) | 367 | 0.48 | 126 | 51 | 241 | 48 |
| age (mean (SD)) | 38.19 | 11.28 | 37.93 | 10.53 | 38.31 | 11.65 |
| BMI (mean (SD)) | 20.20 | 6.19 | 20.73 | 5.64 | 19.89 | 6.49 |
| Risk factors(%) | ||||||
| none reported | 616 | 82.2 | 196 | 79.4 | 420 | 83.7 |
| Family/friend with MDR-TB | 111 | 14.8 | 43 | 17.4 | 68 | 13.5 |
| Worked at clinic/hospital | 22 | 2.9 | 8 | 3.2 | 14 | 2.8 |
| Province (%) | ||||||
| Gauteng | 236 | 31.5 | 81 | 32.8 | 155 | 30.9 |
| Free State | 192 | 25.6 | 51 | 20.6 | 141 | 28.1 |
| Western Cape | 321 | 42.9 | 115 | 46.6 | 206 | 41.0 |
| Employment (%) | ||||||
| No | 351 | 46.9 | 116 | 47 | 235 | 46.8 |
| Yes | 117 | 15.6 | 40 | 16.2 | 77 | 15.3 |
| other | 281 | 37.5 | 91 | 36,8 | 190 | 37,8 |
| Substance abuse (%) | 26 | 3.5 | 5 | 2 | 21 | 4.2 |
| Diabetes Mellitus (%) | 28 | 3.7 | 10 | 4 | 18 | 3.6 |
| Mental Health Concerns (%) | 31 | 4.1 | 10 | 4 | 21 | 4.2 |
| HIV status (%) | ||||||
| negative | 144 | 19.2 | 45 | 18.2 | 99 | 19.7 |
| positive | 581 | 77.6 | 194 | 78.5 | 387 | 77.1 |
| unknown | 24 | 3.2 | 8 | 3.2 | 16 | 3.2 |
| CD4 (median [IQR]) | 133.00 | 51.50, 276.50 | 128.00 | 51.00, 307.50 | 135.50 | 52.00, 272.25 |
| Baseline log viral load (mean (SD)) | 4.56 | 1.49 | 4.33 | 1.55 | 4.75 | 1.43 |
| Baseline ART status (%) | ||||||
| ART interrupted | 42 | 7.2 | 13 | 6.7 | 29 | 7.5 |
| ART naïve | 187 | 32.2 | 62 | 32 | 125 | 32.3 |
| on ART at diagnosis | 193 | 33.2 | 62 | 32 | 131 | 33.9 |
| Unknown | 159 | 27.4 | 57 | 29.4 | 102 | 26.4 |
| TB type (%) | ||||||
| Pulmonary TB (PTB) | 689 | 92.0 | 223 | 90.3 | 466 | 92.8 |
| Extrapulmonary TB (EPTB) | 7 | 0.9 | 3 | 1.2 | 4 | 0.8 |
| PTB+EPTB | 53 | 7.1 | 21 | 8.5 | 32 | 6.4 |
| Newly diagnosed (%) | ||||||
| Newly diagnosed | 303 | 40.5 | 80 | 32.4 | 223 | 44.4 |
| Retreatment | 391 | 52.2 | 148 | 59.9 | 243 | 48.4 |
| Unknown | 55 | 7.3 | 19 | 7.7 | 36 | 7.2 |
| Retreatment type (%) | n = 148 | n = 242 | ||||
| Cured | 21 | 54.3 | 69 | 46.6 | 143 | 59.1 |
| Defaulted | 87 | 22.36 | 43 | 29.1 | 44 | 18.2 |
| Treatment failure | 18 | 4.6 | 10 | 6.8 | 8 | 3.3 |
| Other | 73 | 18.7 | 26 | 17.6 | 47 | 19.4 |
| Smear status (%) | ||||||
| Negative | 333 | 44.5 | 96 | 38.9 | 237 | 47.2 |
| No smear info | 80 | 10.7 | 17 | 6.9 | 63 | 12.5 |
| Positive | 336 | 44.9 | 134 | 54.3 | 202 | 40.2 |
* targeted LPA based RR-TB diagnostic algorithm.