Figure 2.

Performance on the reinforcement learning task as a function of medication. (A) Learning across all participants. The orange line presents gain trials and green line presents loss trials. Opaque area represents the standard error of the five-trial moving mean of the accuracy of each subject. (B) Win-stay-lose-shift (WSLS) behaviour per participant, grouped by medication status. WSLS behaviour was calculated as the percentage of stay trials after a reward minus the percentage of stay trials after a loss. Parkinson’s disease (PD) ON patients show more WSLS behaviour during gain versus loss trials relative to healthy controls (HC). (C) Average accuracy per patient grouped by medication status. Accuracy during loss trials was subtracted from accuracy during gain trials (for separate gain and loss figures, see Supplementary Fig. 4).