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. 2023 May 16;146(9):3676–3689. doi: 10.1093/brain/awad162

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© The Author(s) 2023. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Performance on the reinforcement learning task as a function of medication and depression. (A) Win-stay-lose-shift (WSLS) behaviour per participant, grouped by medication status and impulse control disorder (ICD) class. WSLS behaviour was calculated as the percentage of stay trials after a reward minus the percentage of stay trials after a loss. (B) Average accuracy per patient, grouped medication status and depression status. Accuracy during loss trials was subtracted from accuracy during gain trials (for separate gain and loss figures, see Supplementary Fig. 4). (C) Pearson correlation between depression [Beck Depression Inventory (BDI) scores] and ICD [Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s disease Rating Scale (QUIP-rs) scores]. DEP = depression.