Fig. 4.
Brain regions showing inverted U-shaped trajectory patterns. Scattered plots are the effect size as a function of age, with curves fitted by GAM (blue color) and the best simplified model (red color). Shaded areas around the curves represent standard errors. Dashed vertical lines show peak ages estimated from GAM (blue) and simplified model (red). The sizes of the scattered dots show the square root of model weights (1/variance) for each study. r-IFG: right inferior frontal gyrus, l-IFG: left inferior frontal gyrus, r-IPL: right inferior parietal lobule, l-SMA: left supplementary motor area, l-IPL: left inferior parietal lobule, r-CN: right caudate nucleus, l-Insula: left insula, r-MCC: right middle cingulate cortex.