Table 2.
Potency and Efficacy of Environmental or Serum Based PCB Mixtures Toward the Ryanodine Receptor, Isoform 1, in Rabbit Skeletal Muscle. Values in parenthesis represent the 95% Confidence Interval for a given parameter.
| Type of Sample | Details | Max (% Control) | EC2X (µM) | CA Model Predicted EC2X (µM) |
|---|---|---|---|---|
| School Air | East Chicago | 602 (563–642) | 1.56 (1.30–1.85) | 0.61 |
| Columbus Junction | 585 (547–631) | 1.10 (0.90–1.30) | 0.52 | |
| Lake Fish | Predator | 621 (586–658) | 2.02 (1.72–2.36) | 0.57 |
| Bottom Dwelling | 649 (623–678) | 1.60 (1.41–1.82) | 0.59 | |
| Serum | East Chicago Mother | 640 (571–781) | 1.93 (1.41–2.53) | 1.10 |
| East Chicago Child | 490 (472–510 | 1.45 (1.28–1.63) | 1.13 | |
| Columbus Junction Mother | 419 (399–440) | 2.00 (1.18–3.78) | 1.09 | |
| Columbus Junction Child | 474 (447–506) | 1.91 (1.59–2.25) | 1.19 |