. 2023 Aug 21;29(31):4706–4735. doi: 10.3748/wjg.v29.i31.4706

Table 6.

Efficacy of microRNAs used to predict the prognosis of hepatitis B virus-associated hepatocellular carcinoma

Tissues/serum	miRNA panels	Risk/protective factors	Outcome	HR	CI	Ref.
Tissues	miR-9-3^a	Risk	OS	-	-	[62]
Tissues	miR-10b^a	Risk	OS	-	-	[62]
Tissues	miR-21^b	Risk	DFS	3.019	0.219-6.939	[56]
Tissues	miR-29a-5p^b	Risk	TTR	0.5	0.3-0.8	[63]
Tissues	miR-29a-5p^b	Risk	OS	-	-	[63]
Tissues	miR-31^a	Risk	OS	-	-	[62]
Tissues	miR-106b^a	Risk	OS, DFS	-	-	[64]
Tissues	miR-122^a	Protect	OS	-	-	[54]
Tissues	miR-122^b	Protect	OS	-	-	[55]
Tissues	miR-143^b	Protect	OS	-	-	[55]
Tissues	miR-145^a	Protect	DFS	1.12	0.293-2.958	[56]
Tissues	miR-193b^c	Protect	OS	-	-	[57]
Tissues	miR-203a	Protect	OS	0.63	0.41-0.97	[58]
Tissues	miR-216b^c	Protect	OS, DFS	-	-	[59]
Tissues	miR-224^b	Risk	OS	-	-	[55]
Tissues	miR-371a-5p^b	Risk	OS	-	-	[27]
Tissues	miR-375	Protect	DFS	-	-	[60]
Tissues	miR-375^b	Protect	OS	-	-	[55]
Tissues	miR-384^a	Protect	OS	-	-	[61]
Tissues	miR-519c^a	Risk	OS	-	-	[62]
Tissues	miR-522^a	Risk	OS	-	-	[62]
Tissues	miR-522^b	Risk	OS	2.19	1.33-3.6	[65]
Tissues	miR-523^b	Risk	OS	1.5	1-2.44	[65]
Tissues	miR-3188^c	Risk	OS, DFS	-	-	[28]
Tissues	miR-3660^a	Risk	OS	-	-	[62]
Tissues	miR-3682-3p^c	Risk	OS	-	-	[66]
Tissues	miR-4784^a	Risk	OS	-	-	[62]
Tissues	miR-5188^b	Risk	OS	-	-	[67]
Tissues	miR-6883^a	Risk	OS	-	-	[62]
Serum	miR-24-3p^b	Risk	OS	2.141	1.158-3.960	[33]
Serum	miR-24-3p^b	Risk	DFS	2.055	1.114-3.792	[33]
Serum	miR-29a-3p^b	Risk	OS	4.0	1.2-13.9	[69]
Serum	miR-29a-3p^a	Risk	PFS	-	-	[69]
Serum	miR-96^a	Risk	OS	-	-	[34]
Serum	miR-150^c	Protect	OS	0.446	0.233-0.854	[13]
Serum	miR-192-5p^b	Risk	OS	-	-	[69]
Serum	miR-192-5p^b	Risk	PFS	2.2	1.1-4.2	[69]
Serum	miR-487b^a	Risk	OS	2.846	1.139-7.114	[19]
Serum	miR-487b^c	Risk	OS	2.115	1.083-4.132	[18]
Serum	miR-768-3p^b	Protect	OS	3.057	1.136-8.225	[20]
Plasma	miR-155	Risk	OS	-	-	[70]

P < 0.05.

P < 0.01.

P < 0.001.

OS: Overall survival; DFS: Disease-free survival; TTR: Time to tumor recurrence; PFS: Progression-free survival; HR: Hazard ratio; CI: Confidence interval; miRNAs: MicroRNAs.