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. 2023 Aug 15;15(8):1424–1435. doi: 10.4251/wjgo.v15.i8.1424

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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Flow chart of participant selection. CRC: Colorectal cancer; MT-sDNA: Multi-target stool DNA; FMDI: Fecal microbiota diagnostic index; CEA: Carcinoembryonic antigen; AFP: Alpha-fetoprotein; CA199: Carbohydrate antigen 199; PCA: Principal component analysis; RDA: Redundancy analysis; LEfSe: Linear discriminant analysis effect size.