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. 2023 Jul 17;33(9):661–678. doi: 10.1038/s41422-023-00846-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a UMAP visualization of integration analysis of the remaining cell types after excluding TrB and SNC populations in human embryos and D8 E-assembloids, respectively. b, c Dot plots of candidate genes specific for the indicated cell subtypes in human embryos and D8 E-assembloids. d UMAP plots of the indicated genes expressed in D8 E-assembloids and 3D-cultured embryos. Some cells in ExM2 population exhibit haemato-endothelial characteristics (arrow). e Comparative integration analysis of scRNA-seq datasets from 3D-cultured human embryos, E-assembloids and two other embryo models.^10,14 f Schematic diagram showing 3D morphological feature of D8 E-assembloid. MeLC mesoderm-like cell, m/xEM-m mesoderm/extraembryonic mesoderm, meso mesoderm, TB/Am trophoblast/amnion. See also Supplementary information, Fig. S7.