Figure 8.

Mediation of cardinal asthma-associated traits on genetic risk for asthma

For the PRS associations with asthma, the estimated proportions mediated by eosinophil count (blue), FEV₁/FVC (green), and age of hay fever diagnosis (orange) are shown with 95% confidence intervals. Mediation analysis was conducted separately for COA, AOA, and all asthma. In each instance, the asthma PRS was the independent variable, asthma status was the dependent variable, and one of the three traits was the mediator.