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. 2023 Sep 1;13:14359. doi: 10.1038/s41598-023-41490-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The knockdown of Nrf2 increased the cytotoxic effects of oxaliplatin and lobaplatin on CRC cells. (A) The stable knockdown of Nrf2 in HCT116 and LOVO cells after lentivirus transfection. (B, C) The knockdown of Nrf2 enhanced the inhibitory effects of oxaliplatin and lobaplatin on the viability of CRC cells by the MTS assay. (D–F) Compared to oxaliplatin or lobaplatin alone, the knockdown of Nrf2 combined with oxaliplatin or lobaplatin formed fewer colonies in CRC cells. (G–J) The knockdown of Nrf2 promoted oxaliplatin-induced and lobaplatin-induced apoptosis by flow cytometry. Data are shown as the mean ± SD, *p < 0.05; **p < 0.01; ***p < 0.001; ns (not significant).