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. 2023 Sep 1;13:14360. doi: 10.1038/s41598-023-40751-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of enoxacin for adjuvant therapy in vivo mouse study. Mouse study was performed as described in Fig. 5. (A) Diagram of mice study. Individual tumor volumes in (B) vehicle, (C) etoposide-only and (D) enoxacin following etoposide treatment. (E) Kaplan-Meier plot represents event-free survival. The event was counted when tumor reached 1.4 cc. Overall p-values were calculated using the log-rank test. P = 0.014 for etoposide then enoxacin group compared to vehicle only. (F) The expression of CD133 and cleaved (c)-caspase 3 in EWS xenograft tumors from vehicle, etoposide-only, or enoxacin after etoposide treated groups. Eight protein samples in each group were used for western blot. To compare the protein intensity among immunoblots, one vehicle sample was applied in the first lane of each blot. The relative expression of CD133 and c-caspase 3 was shown in the graph of densitometry analysis.