Table 2.

Etoposide dosing consideration from the literature.

	Human				Mouse
Agent	Dose	AUC^	Fu,p	AUCu	Dose	AUC#	Fu,p	AUCu
Etoposide	100 mg/m2 I.V.	84,000 hr-ng/ml	0.04936	4120 hr-ng/ml	10 mg/kg I.P.	14,300 hr-ng/ml37	0.42336	6050 hr-ng/ml

Fu,p fraction unbound in the plasma. AUCu area under the concentration-time curve for unbound drug.

^{^}Cmax 16.3 ± 3.7 µg/ml (27.7 µM)³⁸.

^#Cmax 32.1 ± 1.9 µg/mL (54.54 µM) for the IV dose, with IP=IV assumed.