Table 2.
Genes mapped to lead single nucleotide polymorphisms within loci jointly associated with anorexia nervosa and at least two related phenotypes.
| Phenotypes | Symbol | Chr | Phenotypes | Symbol | Chr |
|---|---|---|---|---|---|
| MDD, INT | ADARB1 | 21 | Mood, NEUR | LINC00923 | 15 |
| MDD, INT | AMT | 3 | Mood, INT | LRGUK | 7 |
| Mood, NEUR, INT | ARHGAP15 | 2 | SCZ, BIP, MDD, NEUR | MICB | 6 |
| BIP, NEUR | ARNTL | 11 | SCZ, NEUR | MSH5 | 6 |
| BIP, MDD | BAG6 | 6 | SCZ, Mood, NEUR | MSRA | 8 |
| SCZ, NEUR | C2 | 6 | BIP, Mood, NEUR, INT | NCAM1 | 11 |
| SCZ, BIP, MDD, NEUR | C4A | 6 | MDD, INT | NCKIPSD | 3 |
| MDD, INT | CCDC71 | 3 | SCZ, MDD, Mood, INT | NEGR1 | 1 |
| SCZ, BIP, MDD, NEUR | CCHCR1 | 6 | Mood, INT | NEURL2 | 20 |
| SCZ, NEUR | CFB | 6 | MDD, NEUR, INT | OR5AK2 | 11 |
| SCZ, NEUR | CSNK2B | 6 | MDD, NEUR | P4HTM | 3 |
| Mood, INT | CTSA | 20 | Mood, INT | PCIF1 | 20 |
| SCZ, BIP, MDD, NEUR | DDAH2 | 6 | SCZ, MDD, NEUR | PDE4B | 1 |
| MDD, INT | DTNBP1 | 6 | Mood, NEUR | RBM6 | 3 |
| Mood, NEUR | ERI1 | 8 | Mood, NEUR | RNF123 | 3 |
| Mood, INT | EXOC4 | 7 | Mood, INT | SPATA25 | 20 |
| Mood, NEUR | FAM212A | 3 | MDD, Mood, NEUR | TCF4 | 18 |
| BIP, MDD | FLOT1 | 6 | BIP, NEUR | TIMP4 | 3 |
| MDD, Mood, NEUR | GPX1 | 3 | BIP, INT | TRIM26 | 6 |
| BIP, MDD | HLA-B | 6 | SCZ, NEUR, INT | TSNARE1 | 8 |
| SCZ, BIP, MDD, NEUR | HLA-C | 6 | SCZ, BIP, MDD, NEUR, INT | VARS2 | 6 |
| SCZ, NEUR | HLA-DQA1 | 6 | MDD, INT | WDR6 | 3 |
| SCZ, NEUR | HLA-DQB1 | 6 | Mood, INT | ZSWIM1 | 20 |
Note: Genes mapped to lead SNPs within loci jointly associated with AN and at least two related phenotypes (SCZ, BIP, MD, Mood, NEUR, and INT) at conjFDR < 0.05. Genes shared between AN and related phenotypes mapped to genes using positional mapping, eQTL mapping, and chromatin interaction strategies. AN Anorexia nervosa, BIP Bipolar disorder, conjFDR Conjunctional False Discovery Rate, INT Intelligence, Mood Mood instability, NEUR Neuroticism, SCZ Schizophrenia.