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. 2023 Aug 23;55(8):1573–1594. doi: 10.1038/s12276-023-01078-x

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 15 — This figure depicts the process of erebosis, a novel form of cell death observed during the natural turnover of enterocytes that constitute the gut epithelium. Nuclear expansion and accumulation of angiotensin-converting enzyme (ACE) are observed in the early stages of erebosis. Subsequently, cell shrinkage and nuclear fragmentation are observed. Late erebotic cells are surrounded by stem cells that eventually undergo division to generate new epithelial cells, contributing to the replenishment of the gut epithelium.