Skip to main content
. 2023 Sep 1;14:5329. doi: 10.1038/s41467-023-41074-3

Fig. 8. The cecal microbiota from mice fed diet A regulates vena porta bile acid levels and hepatic expression of Shp in mice fed the MF diet.

Fig. 8

Bile acid levels and expression of genes regulated by bile acids in mice fed diet A or MF diet for 9 weeks (a–f) and in mice inoculated with cecal microbiota from mice fed MF or A diet and subsequently fed MF diet for 9 weeks (g–l). a Total vena porta bile acid levels, b vena porta levels of individual bile acids, c redundancy analysis (RDA) plot based on relative bile acid levels in vena porta, d TβMCA/TωMCA and βMCA/ωMCA ratios, e relative ileum expression of Fgf15 and f relative hepatic expression of Shp in mice fed diet A or MF diet. g Total vena porta bile acid levels, h vena porta levels of individual bile acids, i redundancy analysis (RDA) plot based on relative bile acid levels in vena porta, j TβMCA/TωMCA and βMCA/ωMCA ratios, k relative ileum expression of Fgf15, and l relative liver expression of Shp in mice inoculated with cecal microbiota from mice fed MF or A diet and subsequently fed MF diet. a–f: n = 10; g–l: n = 15 (MF microbiota), 14 (A microbiota) except for k where n = 13 for A microbiota. Significant p-values determined by two-sided Mann–Whitney U-test are displayed in the figure. Data are presented as mean ± SEM. MCA muricholic acid, CA cholic acid, CDCA chenodeoxycholic acid, DCA deoxycholic acid, UDCA ursodeoxycholic acid, LCA lithocholic acid, HDCA hyodeoxycholic acid, T taurine-conjugated species, Fgf15 fibroblast growth factor 15, Shp small heterodimer partner. Source data are provided as a Source data file.