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. 2023 Sep 1;8:129. doi: 10.1038/s41541-023-00719-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Direct interactions network of five higher confidence causal transcription factors. b Direct interactions network of five higher confidence causal transcription factors in addition to prolactin (PRL). c Direct interactions network of 33 causal upstream regulators that are known biomarkers for menstrual disturbances. d Direct interactions network of 33 causal upstream regulators that are known biomarkers for menstrual disturbances, in addition to prioritized 5 topological genes and PRL. Thick edges correspond to confidence score $\geq$ 0.70 (i.e., high confidence score), while the thin edge corresponds to a confidence level $\leq$ 0.50 (i.e., low confidence score). Nodes are color-coded using a split pie chart coloring scheme indicating pathway/gene set contribution to each node from the top 5 most enriched pathways/gene lists. FDR values represent he significance of the predicted pathway. Generated based on STRING data on 27 September 2022.