Table 2.

List of menstrual irregularity biomarkers which overlap with BNT162b2 vaccine-induced DEGs and/or predicted causal proteins.

#	Gene	Confidence Score	Activity	Activity Prediction p-value GS1	Activity Prediction p-value GS2	DEG
1	TNF	4	+	3.80E-11	2.96E-03	Yes
2	IL6R	3	+	3.08E-12	1.37E-04	No
3	IL6ST	3	+	3.08E-12	9.00E-05	No
4	LIF	3	+	5.24E-12	2.59E-04	No
5	BIRC3	3	+	8.89E-12	7.63E-06	No
6	FGF2	3	+	3.00E-11	1.18E-03	No
7	ARHGDIB	3	-	7.26E-11	7.63E-06	No
8	RPS3	3	+	1.25E-04	6.27E-03	No
9	RHOU	3	+	4.76E-04	3.60E-03	No
10	MIF	3	+	9.94E-03	3.60E-03	No
11	STAT4	2	+	8.48E-08	NA	No
12	TEK	2	-	4.92E-06	NA	No
13	CXCR4	2	+	9.06E-05	NA	No
14	GAK	2	+	2.67E-04	NA	No
15	ACTN1	2	+	9.62E-04	NA	No
16	PGR	2	-	5.31E-03	NA	No
17	MFN2	2	-	7.00E-03	NA	No
18	EZH2	2	+	7.06E-03	NA	No
19	AXL	2	+	NA	3.69E-03	No
20	IGFBP2	2	+	NA	3.81E-03	No
21	NUB1	1	NA	NA	NA	Yes
22	ICAM1	1	NA	NA	NA	Yes
23	PSME2	1	NA	NA	NA	Yes
24	ADM	1	NA	NA	NA	Yes
25	IL1B	1	NA	NA	NA	Yes
26	HIF1A	1	NA	NA	NA	Yes
27	GDI2	1	NA	NA	NA	Yes
28	PHF19	1	NA	NA	NA	Yes
29	CD1C	1	NA	NA	NA	Yes
30	CTSW	1	NA	NA	NA	Yes
31	KISS1R	1	NA	NA	NA	Yes
32	DLK2	1	NA	NA	NA	Yes
33	CCL5	1	NA	NA	NA	Yes

All molecules were ranked based on their activity prediction p-values as well their overlap confidence score. An overlap confidence score of 3 indicates that a specific gene/protein is overlapping between the biomarker set and 3 other gene sets, while a score of 1 indicates that gene/protein is overlapping between the biomarker list and one other gene set.