Table 3.
List of prolactin biomarkers which overlap with BNT162b2 vaccine-induced DEGs and/or predicted causal proteins.
| # | Gene | Overlap confidence score | Activity | Activity prediction p-value GS1 | Activity prediction p-value GS2 | DEG |
|---|---|---|---|---|---|---|
| 1 | TNF | 3 | + | 3.80E-11 | 2.96E-03 | Yes |
| 2 | MAPK14 | 3 | + | 5.46E-07 | 4.39E-04 | Yes |
| 3 | PPARA | 3 | - | 9.69E-06 | 2.97E-05 | Yes |
| 4 | NFE2L2 | 3 | - | 2.32E-03 | 4.68E-03 | Yes |
| 5 | TXNIP | 3 | - | 3.81E-03 | 1.29E-03 | Yes |
| 6 | IL6R | 2 | + | 3.08E-12 | 1.37E-04 | No |
| 7 | GNAS | 2 | + | 9.79E-12 | 1.79E-05 | No |
| 8 | GNAI2 | 2 | + | 1.53E-10 | 6.06E-05 | No |
| 9 | DRD1 | 2 | + | 3.56E-09 | 4.88E-04 | No |
| 10 | TERT | 2 | + | 9.22E-07 | 5.48E-06 | No |
| 11 | S100A6 | 2 | - | 1.36E-05 | 7.83E-05 | No |
| 12 | FLT1 | 2 | + | 2.01E-05 | 1.63E-04 | No |
| 13 | CDH1 | 2 | - | 3.28E-05 | 3.64E-04 | No |
| 14 | MIR516A2 | 2 | + | 9.57E-04 | 8.45E-03 | No |
| 15 | MIR516A1 | 2 | - | 9.57E-04 | 8.45E-03 | No |
| 16 | MIF | 2 | + | 9.94E-03 | 3.60E-03 | No |
| 17 | VEGFA | 1 | + | 9.58E-10 | NA | No |
| 18 | E2F1 | 1 | + | 1.48E-04 | NA | No |
| 19 | MIR576 | 1 | - | 4.01E-04 | NA | No |
| 20 | FTO | 1 | - | 3.30E-03 | NA | No |
| 21 | AHSG | 1 | + | 4.74E-03 | NA | No |
| 22 | MIR488 | 1 | - | NA | 9.72E-06 | No |
| 23 | CREB1 | 1 | + | NA | 2.59E-04 | No |
| 24 | AKT1 | 1 | + | NA | 2.17E-03 | No |
| 25 | NOS2 | 1 | + | NA | 5.91E-03 | No |
| 26 | TPT1 | 1 | + | NA | 6.27E-03 | No |
| 27 | CASP3 | 1 | - | NA | 6.47E-03 | No |
| 28 | CCL2 | 1 | NA | NA | NA | Yes |
| 29 | CD274 | 1 | NA | NA | NA | Yes |
| 30 | IFI44 | 1 | NA | NA | NA | Yes |
| 31 | MX2 | 1 | NA | NA | NA | Yes |
| 32 | IL1B | 1 | NA | NA | NA | Yes |
| 33 | BMPR2 | 1 | NA | NA | NA | Yes |
| 34 | PARP1 | 1 | NA | NA | NA | Yes |
| 35 | SERPINF2 | 1 | NA | NA | NA | Yes |
All molecules were ranked based on their activity prediction p-values as well their overlap confidence score. An overlap confidence score of 3 indicates that a specific gene/protein is overlapping between the biomarker set and 3 other gene sets, while a score of 1 indicates that gene/protein is overlapping between the biomarker list and one other gene set.